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Ubiquitin Proteasome System Activation

Meaning

Ubiquitin Proteasome System Activation refers to the necessary enhancement of the primary non-lysosomal pathway responsible for the targeted degradation of intracellular proteins within all eukaryotic cells. This intricate process is absolutely crucial for maintaining cellular quality control, efficiently removing damaged or misfolded proteins, and regulating the half-life of critical signaling molecules, including many hormone receptors and transcription factors. Proper activation is essential for robust cellular homeostasis and resistance to age-related dysfunction and proteotoxicity.