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Ubiquitin-Proteasome Pathway Regulation

Meaning

The clinical strategy of modulating the activity of the Ubiquitin-Proteasome System (UPS), the principal non-lysosomal pathway responsible for targeted protein degradation within cells. Precise regulation is essential for maintaining cellular homeostasis, as dysregulation can lead to either excessive protein breakdown, contributing to muscle wasting (catabolism), or inadequate clearance of damaged proteins, leading to cellular toxicity and aging. Optimization aims to balance protein turnover for health and longevity.