Question 1

What is the Meaning of (TTTA)n Repeat?

Accepted Answer

The (TTTA)n Repeat refers to a variable number tandem repeat polymorphism located within the promoter region of the human Androgen Receptor (AR) gene. The subscript 'n' signifies the varying number of these short tetranucleotide repeats found in an individual's DNA sequence. This genetic variation is a crucial determinant of the efficiency with which the AR gene is transcribed into its functional protein.

Question 2

What is the Origin of (TTTA)n Repeat?

Accepted Answer

This genetic variation originates within the coding sequence of the Androgen Receptor gene, which is located on the X chromosome. The clinical significance of this repeat length emerged from molecular genetics studies focused on understanding individual variability in androgen action and sensitivity. It represents a common polymorphism within the human endocrine system's regulatory architecture.

Question 3

What is the Mechanism of (TTTA)n Repeat?

Accepted Answer

The length of the (TTTA)n repeat sequence inversely correlates with the transcriptional activity of the Androgen Receptor gene. Shorter repeat lengths generally result in a more active promoter, leading to higher AR protein expression and consequently, greater cellular sensitivity to circulating androgens like testosterone and dihydrotestosterone. Conversely, longer repeats are associated with reduced AR activity, influencing the clinical presentation and therapeutic response in conditions related to hormonal health.

(TTTA)n Repeat

Meaning

Origin

Mechanism

What Specific Genetic Markers Affect Testosterone Conversion to Estrogen?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours