What is the Origin of Tsp-1 Gene?

Thrombospondin-1 was first identified in the late 1970s as a component of the extracellular matrix. The study of the Tsp-1 gene and its protein product gained significant attention in cancer research due to its potent anti-angiogenic properties. Its current relevance in wellness stems from its broader role in tissue remodeling, inflammation, and its connection to metabolic regulators like the CD47 receptor.

What is the Mechanism of Tsp-1 Gene?

Tsp-1 exerts its function by binding to several cell surface receptors, most notably CD47, which mediates its anti-angiogenic and anti-proliferative effects. By binding to CD47, Tsp-1 inhibits nitric oxide signaling, leading to vasoconstriction and reduced blood flow, which impacts tissue oxygenation and nutrient delivery. Modulation of Tsp-1 activity is being explored as a therapeutic avenue to influence tissue repair and cellular longevity pathways.

Tsp-1 Gene ∞ Area

Tsp-1 Gene

Meaning

The Tsp-1 Gene, officially known as the Thrombospondin-1 gene, encodes for the glycoprotein Thrombospondin-1, which is a multifunctional protein involved in cell-to-cell and cell-to-matrix interactions. In the hormonal and longevity domain, Tsp-1 is particularly noted for its role as an endogenous inhibitor of angiogenesis (new blood vessel formation) and its influence on cellular senescence and the tumor microenvironment. Its expression level is a relevant factor in processes related to tissue aging and metabolic health.