Tryptophan Rich Foods are dietary sources that contain high concentrations of the essential amino acid L-tryptophan, which serves as a critical biochemical precursor for the synthesis of the neurotransmitter serotonin and the chronobiotic hormone melatonin. Integrating these foods into the diet is a fundamental nutritional strategy for supporting healthy mood regulation, cognitive function, and the synchronization of the sleep-wake cycle. The bioavailability of tryptophan is influenced by co-ingestion of carbohydrates, which facilitate its transport across the blood-brain barrier.
Origin
This term is rooted in nutritional biochemistry and neuroendocrinology, focusing on the essential amino acid Tryptophan and its presence in specific Foods. It links diet directly to neurohormonal health.
Mechanism
Upon ingestion, L-tryptophan is absorbed and transported across the blood-brain barrier, where it is converted into 5-hydroxytryptophan (5-HTP) by the enzyme tryptophan hydroxylase, which is the rate-limiting step. Subsequently, 5-HTP is converted to serotonin (5-HT) and, in the pineal gland, further metabolized into melatonin. By providing the necessary substrate, tryptophan-rich foods support the endogenous synthesis of these neurohormones, which are vital for modulating circadian rhythm, promoting sleep propensity, and regulating mood.
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