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Tryptophan Metabolism Balancing

Meaning

Tryptophan Metabolism Balancing is the clinical strategy focused on regulating the biochemical pathways that process the essential amino acid tryptophan, ensuring its optimal partitioning toward beneficial neuroactive metabolites, particularly serotonin and melatonin, while limiting the production of potentially inflammatory kynurenine pathway metabolites. Tryptophan is a crucial precursor for numerous signaling molecules, making the balance of its metabolism fundamental for mood regulation, sleep quality, and systemic immune function. Dysregulation, often driven by chronic inflammation, can deplete serotonin synthesis and increase neurotoxic byproducts.