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Tryptophan-Kynurenine Pathway

Meaning

The Tryptophan-Kynurenine Pathway is the principal metabolic cascade for the essential amino acid L-tryptophan, leading to the sequential production of kynurenine and its subsequent metabolites, including the neuroactive compounds quinolinic acid and kynurenic acid. This pathway serves as a critical biochemical interface, linking the immune system, the gut microbiome, and the neuroendocrine regulation of stress and mood. The proper flux through this pathway is essential for maintaining neurological health.