What is the Origin of TRT Pellets?

The use of hormone pellets dates back to the 1930s, offering one of the earliest methods for sustained hormone delivery. Their modern resurgence in TRT is valued for the pharmacokinetic advantage of maintaining stable serum testosterone levels, avoiding the significant peaks and troughs associated with other administration routes.

What is the Mechanism of TRT Pellets?

The mechanism of action is passive diffusion; the compressed testosterone compound slowly dissolves into the surrounding subcutaneous tissue and then enters the bloodstream at a relatively constant rate. This consistent, non-pulsatile release helps maintain a steady physiological concentration, which minimizes the fluctuations in mood and energy often reported with intermittent dosing schedules and simplifies patient adherence to the treatment protocol.

TRT Pellets ∞ Area

TRT Pellets

Meaning

TRT Pellets, or subcutaneous testosterone pellets, are a form of long-acting Testosterone Replacement Therapy (TRT) involving the surgical implantation of small, solid hormone reservoirs beneath the skin, typically in the hip or buttocks area. These pellets slowly and continuously release a bioidentical dose of testosterone over a period of three to six months, providing a steady-state delivery system that bypasses the need for frequent injections or daily topical application.