What is the Origin of TRT Hair Loss?

The term is a clinical abbreviation, combining the therapeutic intervention TRT (Testosterone Replacement Therapy) with the common side effect of Hair Loss. It is a recognized adverse effect within the practice of men's health and endocrinology.

What is the Mechanism of TRT Hair Loss?

Exogenous testosterone administered during TRT increases the substrate available for the enzyme 5-alpha reductase, which is highly expressed in hair follicles. This enzyme converts testosterone into DHT, a potent androgen that binds to receptors in the scalp, triggering the miniaturization of genetically susceptible hair follicles. The resulting progressive reduction in hair follicle size leads to the characteristic thinning and pattern of hair loss, requiring the use of 5-alpha reductase inhibitors or other topical agents for management.

TRT Hair Loss

Meaning

TRT Hair Loss describes the phenomenon of accelerated or induced androgenic alopecia (pattern baldness) that can occur as an unintended consequence of Testosterone Replacement Therapy (TRT). This side effect is not caused by testosterone itself but by its conversion into the more potent androgen, Dihydrotestosterone (DHT). Clinically, this is a significant concern for patients and requires proactive management strategies to mitigate the aesthetic and psychological impact while maintaining therapeutic testosterone levels.