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TRT Discontinuation

Meaning

TRT Discontinuation refers to the cessation of Testosterone Replacement Therapy, a clinical decision that can be planned and managed or necessitated by adverse effects or changes in therapeutic goals. Stopping exogenous testosterone results in a temporary or prolonged state of hypogonadism, as the body’s endogenous production has typically been suppressed by the therapy’s negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis. The process requires careful clinical oversight to manage potential withdrawal symptoms and facilitate the recovery of native testosterone production.