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Trophic Factor Cascade

Meaning

Trophic Factor Cascade describes the sequential and interconnected release and action of various endogenous signaling molecules, including neurotrophins, growth factors, and cytokines, that collectively govern cellular growth, survival, and differentiation within a tissue. This cascade is a complex biological amplification system, where the initial release of one factor can trigger the production of several others, leading to a widespread and coordinated cellular response. In hormonal health, this system is vital for tissue repair, muscle hypertrophy, and maintaining neural integrity. Disruptions in this cascade can impair regenerative capacity and accelerate age-related functional decline across multiple organ systems.