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TrkB Receptor Activation

Meaning

TrkB receptor activation refers to the binding and subsequent intracellular signaling cascade initiated by Brain-Derived Neurotrophic Factor (BDNF) upon its specific, high-affinity receptor, Tropomyosin Receptor Kinase B (TrkB). This activation is a critical molecular event that supports neuronal survival, promotes synaptic plasticity, and drives neurogenesis, playing a vital role in cognitive function, mood regulation, and the overall health of the central nervous system. Its function is intimately linked to the regulation of the stress axis and metabolic health, providing a key link between exercise and brain health.