What is the Origin of Transdermal Progesterone Support?

This method originates in pharmaceutical science and clinical endocrinology, seeking to overcome the pharmacokinetic limitations of oral steroid administration. "Transdermal" refers to the route of absorption, and "Progesterone Support" emphasizes the hormone's crucial role in endometrial health, mood regulation, and bone maintenance.

What is the Mechanism of Transdermal Progesterone Support?

The mechanism involves the progesterone molecule passively diffusing across the stratum corneum and into the systemic circulation, where it can then bind to progesterone receptors (PR-A and PR-B) in target cells. By avoiding hepatic metabolism, the transdermal route reduces the formation of sedative metabolites and minimizes the impact on hepatic protein synthesis, such as SHBG. This allows for a more direct and sustained delivery of the active hormone to peripheral tissues.

Transdermal Progesterone Support ∞ Area

Transdermal Progesterone Support

Meaning

Transdermal Progesterone Support is a therapeutic modality involving the administration of bio-identical progesterone through the skin, typically via a cream, gel, or patch, to achieve systemic circulation and target tissue effects. This delivery route is favored clinically to bypass the extensive first-pass metabolism that occurs when progesterone is taken orally, leading to more predictable and physiologically relevant serum concentrations. It is a common intervention for balancing estrogen effects and supporting neuroendocrine health.