What is the Origin of Transdermal Hormone Kinetics?

This arises from the clinical need to administer lipophilic hormones without subjecting them to first-pass hepatic metabolism, which occurs with oral administration. Transdermal delivery utilizes the skin as a reservoir for sustained release.

What is the Mechanism of Transdermal Hormone Kinetics?

Kinetics are primarily governed by the physicochemical properties of the specific steroid molecule, such as its molecular weight and lipophilicity. The integrity of the stratum corneum acts as the main barrier to absorption. The vehicle formulation dictates the rate of diffusion, directly influencing the resulting plasma concentration curve and the duration of therapeutic effect.

Transdermal Hormone Kinetics ∞ Area

Transdermal Hormone Kinetics

Meaning

The study describing the absorption profile, systemic distribution, metabolic clearance rate, and ultimate fate of steroid hormones administered via topical skin application. Understanding kinetics is crucial for effective transdermal therapy dosing. This defines how much hormone reaches the systemic circulation over time.