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Transdermal Hormone Delivery

Meaning

Transdermal hormone delivery is a pharmacological method of administering steroid hormones, such as testosterone or estradiol, directly through the skin and into the systemic circulation, bypassing the gastrointestinal tract and first-pass hepatic metabolism. This route is typically achieved using patches, gels, creams, or sprays, offering a non-invasive alternative to injections or oral preparations. Clinically, this method is valued for its ability to provide relatively stable, continuous hormone concentrations, which can more closely mimic the body’s natural physiological secretion patterns. Proper application technique is crucial for ensuring consistent absorption and therapeutic efficacy.