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Transdermal Gel

Meaning

A transdermal gel is a semisolid pharmaceutical preparation designed for application to the skin, serving as a delivery vehicle for active pharmaceutical ingredients, such as hormones, to be absorbed through the skin into the systemic circulation. This non-invasive route of administration offers a convenient alternative to oral tablets or injections. Clinically, transdermal gels are often preferred in hormonal therapy to achieve more stable serum concentrations and bypass the hepatic first-pass metabolism, potentially improving the safety profile.