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Transdermal Estrogen Therapy

Meaning

Transdermal Estrogen Therapy is a hormone replacement modality that involves the application of estrogen directly onto the skin, typically utilizing a patch, gel, spray, or cream, to allow for systemic absorption into the bloodstream. This delivery route is clinically favored because it effectively bypasses the hepatic first-pass metabolism that occurs with oral estrogen administration, resulting in a significantly more favorable cardiovascular and thrombotic risk profile. It is a cornerstone of modern, safer management for menopausal symptoms, hypogonadism, and other forms of estrogen deficiency.