What is the Origin of Transdermal Delivery Efficacy?

This term originates from pharmaceutics and dermatological science, where "transdermal" refers to absorption through the skin barrier. "Efficacy" quantifies the success of this delivery route in achieving systemic effect, a key consideration in modern hormone replacement.

What is the Mechanism of Transdermal Delivery Efficacy?

The mechanism involves the active agent diffusing across the lipid layers of the epidermis, often aided by permeation enhancers within the vehicle matrix. Once in the dermis, the compound enters the capillary network for systemic distribution, bypassing first-pass hepatic metabolism entirely. Monitoring plasma or salivary levels post-application determines the actual systemic dose absorbed versus the applied dose.

Transdermal Delivery Efficacy ∞ Area

Transdermal Delivery Efficacy

Meaning

Transdermal Delivery Efficacy measures the actual rate and extent to which an active compound, typically a hormone or peptide, penetrates the stratum corneum and enters the systemic circulation from a topical application site. This is a critical metric for non-oral therapies, as bioavailability can vary significantly based on formulation and individual skin characteristics. High efficacy ensures predictable therapeutic levels are achieved without the pitfalls of oral administration. We seek consistent absorption kinetics.