What is the Meaning of Transdermal Delivery?

A method of systemic drug administration where an active therapeutic agent, such as a hormone, is delivered across the skin barrier and into the bloodstream for systemic circulation. This non-invasive route bypasses the gastrointestinal tract and the hepatic first-pass metabolism, offering a steady, sustained release of the compound. It is a common and clinically advantageous method for administering bioidentical hormones.

What is the Origin of Transdermal Delivery?

The concept of using the skin for drug delivery dates back centuries, but modern transdermal patches and gels were scientifically developed and commercialized in the late 20th century. This innovation was driven by the need to improve bioavailability and reduce the side effects associated with oral administration of certain drugs. It is a key pharmaceutical engineering advancement.

What is the Mechanism of Transdermal Delivery?

The drug is formulated to penetrate the stratum corneum, the outermost layer of the skin, typically through passive diffusion down a concentration gradient. Once in the deeper layers of the epidermis and dermis, the drug is absorbed into the local capillaries and then enters the systemic circulation. This mechanism maintains relatively stable plasma concentrations, avoiding the sharp peaks and troughs seen with some oral dosing.

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What Are the Pharmacokinetic Differences between Injected and Transdermal Testosterone Delivery?

Injected testosterone creates a peak-and-trough hormonal environment, while transdermal delivery provides a more stable, physiological state.

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Can Oral Hormone Therapy Influence Long-Term Cardiovascular Health Outcomes?

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