What is the Origin of Transdermal Absorption Efficiency?

The term is rooted in pharmaceutical science and dermatology, specifically the study of drug delivery systems. The concept of 'Efficiency' is a measure of bioavailability via the transdermal route, contrasting with oral or injectable administration. Research in this area focuses on enhancing skin permeability to maximize therapeutic delivery and minimize variability.

What is the Mechanism of Transdermal Absorption Efficiency?

The mechanism of absorption involves the passive diffusion of the lipophilic hormone molecule across the stratum corneum, the outermost layer of the skin, followed by penetration into the deeper, vascularized dermal layers where it enters the systemic bloodstream. Efficiency is governed by Fick's Law of Diffusion, influenced by the concentration gradient and the skin's resistance to permeability. Optimized formulations often use chemical enhancers to temporarily disrupt the lipid bilayer of the stratum corneum, increasing the flux of the hormone into the circulation.

Transdermal Absorption Efficiency ∞ Area

Transdermal Absorption Efficiency

Meaning

Transdermal Absorption Efficiency refers to the measurable percentage of an applied substance, such as a hormone in a cream or gel, that successfully permeates the skin barrier and enters the systemic circulation in its active form. This efficiency is a critical pharmacokinetic factor in hormonal therapy, as it is highly dependent on the molecule’s physiochemical properties, the vehicle formulation, and individual skin characteristics. Clinicians must account for this variable rate to ensure accurate and consistent dosing.