What is the Origin of Transdermal 17β-Estradiol?

The term is purely descriptive, combining "Transdermal" (meaning through the skin) with the precise chemical name for the active, bioidentical hormone, "17β-Estradiol." The development of this delivery method was a significant advancement in hormone therapy, addressing the metabolic concerns associated with oral administration.

What is the Mechanism of Transdermal 17β-Estradiol?

Upon application to the skin, the 17β-estradiol passively diffuses across the stratum corneum and is absorbed directly into the systemic circulation. By avoiding the portal vein and hepatic circulation, this delivery method minimizes the hormone's impact on liver protein synthesis, including clotting factors and sex hormone-binding globulin (SHBG). This key clinical advantage provides a more consistent, physiological hormonal profile while potentially reducing the risk of thrombotic events.

Transdermal 17β-Estradiol

Meaning

Transdermal 17β-Estradiol is a method of bioidentical hormone therapy where the body’s primary and most potent endogenous estrogen, 17-beta estradiol (E2), is delivered directly through the skin via patches, gels, or sprays. This route of administration is a clinically preferred option for hormone replacement because it completely bypasses the liver’s extensive first-pass metabolism. The transdermal approach results in a more stable, physiological ratio of estradiol to estrone and is widely utilized to effectively manage menopausal symptoms and mitigate osteoporosis risk.