What is the Meaning of Transdermal?

Transdermal describes a route of administration for therapeutic agents, such as hormones, where the substance is delivered through the skin and into the systemic circulation for therapeutic effect. This method bypasses the first-pass metabolism in the liver, which can be a significant advantage for certain compounds like testosterone or estradiol, offering more stable and predictable serum concentrations. Transdermal delivery systems, including patches, gels, and creams, are a cornerstone of modern, personalized hormone replacement therapy.

What is the Origin of Transdermal?

The term is a compound of the Latin prefix trans- (across, through) and the Greek word derma (skin). The clinical application of transdermal drug delivery began in the 1970s, moving beyond topical local effects to achieve systemic therapeutic concentrations. This route was specifically developed to improve patient compliance and pharmacokinetic profiles for drugs that are poorly absorbed orally or subject to extensive hepatic metabolism.

What is the Mechanism of Transdermal?

The mechanism of transdermal absorption relies on the passive diffusion of the drug molecule from the application site, through the stratum corneum—the outermost layer of the skin—and into the dermal microcirculation. The rate of absorption is influenced by the drug's lipophilicity, molecular size, and the use of chemical enhancers in the formulation. Once in the capillaries of the dermis, the hormone enters the bloodstream, where it can travel to distant target receptors to exert its systemic endocrine effects.

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