What is the Origin of Transcription Factor Activation?

This concept is fundamental to molecular biology and genetics, describing the control points of gene expression.

What is the Mechanism of Transcription Factor Activation?

Activation often requires post-translational modifications, such as phosphorylation by kinases stimulated by hormone receptor signaling, leading to conformational changes that expose the DNA-binding domain or nuclear localization signal.

Transcription Factor Activation ∞ Area

Transcription Factor Activation

Meaning

Transcription Factor Activation is the molecular event where a regulatory protein gains the ability to bind to specific DNA sequences, thereby initiating or repressing the transcription of downstream target genes.