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Transappendegeal Pathway Utilization

Meaning

The strategic use of the skin’s accessory structures, specifically the hair follicles and eccrine sweat glands, as alternative conduits for the absorption of therapeutic compounds into the underlying viable skin and systemic circulation. While this route is generally considered a minor absorption pathway, it can become significant for certain molecules, particularly those that are highly polar or possess unfavorable characteristics for traversing the main stratum corneum barrier. It offers a valuable, alternative shunt route for systemic drug delivery.