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Trained Immunity

Meaning

Trained Immunity is the concept that innate immune cells, such as monocytes and natural killer cells, can acquire a form of immunological memory following initial exposure to certain microbial components or vaccines. This “training” results in a non-specific enhanced functional response to a subsequent, unrelated challenge, lasting for an extended period. This epigenetic reprogramming of innate cells offers a new perspective on immune system modulation and longevity.