Question 1

What is the Meaning of TR/RXR Heterodimer?

Accepted Answer

The TR/RXR Heterodimer is a functional protein complex formed by the physical association of the Thyroid Hormone Receptor (TR) and the Retinoid X Receptor (RXR), both belonging to the nuclear receptor superfamily. This heterodimer represents the essential molecular machinery that binds to specific DNA sequences in the nucleus to regulate gene transcription in response to thyroid hormone (T3). It is the central mechanism for translating the endocrine signal into a cellular metabolic response.

Question 2

What is the Origin of TR/RXR Heterodimer?

Accepted Answer

This is a core molecular biology term in endocrinology, specifically describing the protein complex responsible for mediating the genomic actions of thyroid hormone. 'TR' is the Thyroid Receptor, 'RXR' is the Retinoid X Receptor, and 'Heterodimer' indicates a complex of two different protein subunits.

Question 3

What is the Mechanism of TR/RXR Heterodimer?

Accepted Answer

In the absence of T3, the TR/RXR heterodimer binds to Thyroid Hormone Response Elements (TREs) on the DNA, often recruiting Nuclear Receptor Corepressors to silence gene expression. Upon the binding of T3 to the TR subunit, a critical conformational change occurs, leading to the dissociation of corepressors and the recruitment of coactivator proteins. This exchange initiates chromatin remodeling and the activation of target gene transcription, driving the body's metabolic rate and development.

TR/RXR Heterodimer

Meaning

Origin

Mechanism

How Do Lifestyle Interventions Influence Thyroid Hormone Receptor Sensitivity?

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