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Tolerogenic Nanoparticles

Meaning

Tolerogenic nanoparticles are sophisticated, microscopic synthetic structures engineered to encapsulate and deliver specific antigens or immunomodulatory molecules to immune cells, with the deliberate goal of inducing immunological tolerance. This therapeutic approach aims to retrain the immune system to recognize a target self-antigen as harmless, effectively stopping an autoimmune response without the need for generalized immunosuppression. In the realm of hormonal health, these agents hold immense promise for treating autoimmune endocrinopathies like Type 1 diabetes or autoimmune thyroid disease.