The complex, coordinated physiological process by which damaged or injured biological tissues restore their structural integrity and functional capacity, involving overlapping phases of inflammation, proliferation, and remodeling. This fundamental process is highly dependent on a balanced hormonal environment, with anabolic signals like Growth Hormone and testosterone playing a critical role in cellular regeneration.
Origin
This term is central to pathology and physiology, describing the body’s intrinsic ability to heal itself following trauma or disease. The modern understanding integrates cellular signaling, immunology, and endocrinology to explain the precision of the restorative process.
Mechanism
The process begins with immediate hemostasis and an inflammatory phase to clear debris and pathogens, regulated in part by cortisol. This is followed by the proliferative phase, where fibroblasts deposit new collagen and epithelial cells regenerate, a stage significantly accelerated by Growth Hormone and Insulin-like Growth Factor 1 (IGF-1). Finally, the remodeling phase organizes the new tissue, demonstrating the body’s sophisticated, hormone-mediated capacity for regeneration and functional restoration.
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