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Tissue Specific Estrogen Action

Meaning

Tissue Specific Estrogen Action refers to the differential biological effects of estrogen, or selective estrogen receptor modulators (SERMs), across various organ systems due to the presence of distinct estrogen receptor subtypes (ERα and ERβ) and co-regulatory proteins. This clinical principle acknowledges that estrogen’s influence is not uniform but highly contextual, allowing for targeted therapeutic strategies that can be anabolic in one tissue, such as bone, while being neutral or anti-proliferative in another, such as breast or uterine tissue. It is the basis for precision hormone therapy.