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Tissue Specific Clock Genes

Meaning

A network of core molecular transcription factors, such as Per and Cry, that govern the precise 24-hour rhythmic expression of thousands of genes within specific peripheral organs and tissues, distinct from the brain’s master clock. These genes allow organs like the liver, pancreas, and adrenal glands to anticipate and optimize their function based on the expected time of day, aligning metabolism and hormone synthesis with behavioral cycles. Disruption of these tissue-specific clocks is a key factor in metabolic and endocrine disorders. Maintaining their synchronization is crucial for metabolic health.