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Tissue Responsiveness Modulation

Meaning

Tissue Responsiveness Modulation describes the dynamic process by which target cells actively alter their functional output or sensitivity in response to a constant or changing concentration of a circulating hormone, typically achieved through adjusting receptor numbers or downstream signaling efficiency. This adaptive mechanism is crucial for preventing receptor exhaustion under chronic stimulation or for compensating for subtle fluctuations in endocrine output, thereby maintaining precise physiological control. It reflects the inherent plasticity of the receptive cell.