What is the Origin of Tissue Repair Signalling?

This combines "Tissue Repair," the biological restoration of structure, with "Signalling," the transmission of information via molecular messengers. The concept is foundational to wound healing and regeneration across all organ systems. It describes the directed molecular communication required for biological mending.

What is the Mechanism of Tissue Repair Signalling?

Following injury, initial inflammatory signals trigger the release of local factors and systemic hormones, such as Insulin-like Growth Factor 1 (IGF-1) and testosterone, which stimulate satellite cells or progenitor cells to enter the cell cycle. These factors modulate matrix metalloproteinases (MMPs) and their inhibitors, ensuring the correct deposition and remodeling of the extracellular matrix during the proliferative and maturation phases. This complex interplay requires precise temporal regulation for scarless healing.

Tissue Repair Signalling

Meaning

The coordinated cascade of molecular events involving growth factors, cytokines, and hormones that orchestrate the processes of inflammation resolution, proliferation, and matrix remodeling necessary to restore damaged tissue architecture and function. Optimal signaling is essential for returning physiological parameters to baseline following injury or intense physiological demand. Anabolic hormones are central players here.