The complex, sequential biochemical and cellular events initiated following tissue damage or stress designed to restore normal structure and function through inflammation, proliferation, and remodeling phases. In hormonal health, the efficiency of these cascades is highly dependent on the availability and timing of specific signaling molecules. These sequences dictate the speed and quality of recovery.
Origin
This terminology is standard in wound healing and pathology, describing the organized biological program activated after injury. “Cascades” highlights the dependent, step-wise nature of the molecular events involved.
Mechanism
The initial phase involves inflammatory signaling to clear debris, followed by the proliferation of fibroblasts and endothelial cells, often driven by local growth factors released in response to hormonal cues. Adequate systemic support, particularly sufficient anabolic hormones and building blocks, is required to fuel the synthesis of new extracellular matrix components. Impaired endocrine signaling can stall the cascade in the inflammatory phase, leading to fibrosis or incomplete healing.
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