What is the Origin of Tissue Repair Angiogenesis?

The term combines "tissue repair," the biological process of restoring damaged structures, with "angiogenesis," derived from the Greek words angeion (vessel) and genesis (creation). The concept gained prominence in the study of wound healing, regenerative medicine, and oncology, where its regulation is key.

What is the Mechanism of Tissue Repair Angiogenesis?

The process is initiated by local tissue hypoxia and the release of pro-angiogenic signaling molecules, notably Vascular Endothelial Growth Factor (VEGF). These factors bind to receptors on endothelial cells, stimulating their proliferation, migration, and assembly into new capillary networks. Hormones, including certain sex steroids and growth hormone, act as modulators, enhancing the efficiency of this neovascularization process essential for deep biological restoration.

Tissue Repair Angiogenesis ∞ Area

Tissue Repair Angiogenesis

Meaning

The highly regulated physiological process involving the formation of new blood vessels from pre-existing vasculature, which is a critical, rate-limiting step in tissue regeneration and wound healing. Angiogenesis ensures the necessary delivery of oxygen, nutrients, growth factors, and immune cells to the damaged site, while also facilitating the removal of waste products. It is a fundamental process in maintaining the structural and functional integrity of all organ systems.