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Tissue Remodeling

Meaning

Tissue remodeling is the continuous, highly regulated physiological process by which a mature, existing tissue undergoes systematic structural reorganization through the balanced, coupled degradation and subsequent synthesis of its cellular and extracellular components. This essential process enables dynamic tissues like bone, skin, and muscle to adapt precisely to changing mechanical stresses, effectively repair micro-damage, and maintain their functional integrity throughout the lifespan. Hormonal signals, mechanical load, and local inflammatory mediators are the primary systemic drivers that tightly regulate the precise rate and direction of this constant renewal. A chronic disruption of this crucial balance is a central feature in many age-related and chronic degenerative diseases.