Tissue Regeneration Cascade describes the sequential, highly organized biological program required to restore the structure and functional integrity of damaged or senescent tissue. This cascade involves distinct phases, moving from initial injury response to complete structural restoration. Understanding the initiation and progression of this sequence is central to effective regenerative medicine. This is the body’s intrinsic repair blueprint in action.
Origin
The term is derived from developmental biology and wound healing research, where the orderly progression of cell recruitment and differentiation is meticulously studied. Its application here focuses on reactivating or supporting this natural sequence in aging or injury.
Mechanism
The cascade begins with the resolution of acute inflammation, followed by the activation and proliferation of local progenitor cells or stem cells. Subsequently, these cells differentiate into the appropriate functional phenotypes required for the specific tissue type. Systemic hormones and local growth factors act as sequential signals, ensuring that matrix remodeling and vascular support occur in the correct temporal order.
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