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Tissue Catabolism Favoring

Meaning

Tissue Catabolism Favoring describes a net physiological state where the rate of cellular breakdown and degradation (catabolism) exceeds the rate of cellular repair and synthesis (anabolism) within specific tissues, notably muscle and bone. This imbalance is often driven by a shift in the endocrine milieu, characterized by elevated catabolic hormones like cortisol and insufficient anabolic signals like growth hormone and testosterone. A sustained catabolism-favoring state leads to sarcopenia, frailty, and a loss of structural integrity, negatively impacting longevity.