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TIP39

Meaning

TIP39, or Tuberoinfundibular Peptide of 39 residues, is an endogenous, secreted peptide that functions as the specific, high-affinity ligand for the parathyroid hormone 2 receptor (PTH2R). This receptor system is expressed predominantly in the central nervous system, particularly in regions like the hypothalamus and amygdala, rather than in the bone or kidney like the classic PTH receptor. Clinically, TIP39 is a subject of research for its potential neuromodulatory roles in regulating stress responses, pain perception, and various neuroendocrine functions.