The measurable physiological and metabolic advantages derived from consistently consuming all daily caloric intake within a shortened window, typically eight to twelve hours, without necessarily reducing total caloric load. These benefits include enhanced insulin sensitivity, improved circadian rhythm alignment, and the activation of cellular repair pathways like autophagy. It is a powerful non-pharmacological tool for metabolic and hormonal health.
Origin
This practice is a form of intermittent fasting, with the ‘time-restricted feeding’ term specifically defining the constraint based on the time of day, aligning with chronobiology principles. The scientific investigation into its benefits accelerated with the understanding of the central role of the circadian clock in metabolic regulation.
Mechanism
The primary mechanism involves extending the daily fasting period, which triggers a metabolic switch from glucose utilization to fat oxidation and ketone body production. This extended fasting state enhances insulin sensitivity and promotes the expression of sirtuins and AMPK, key regulators of cellular stress resistance and longevity. The timing constraint also synchronizes the liver and gut clocks with the central brain clock, optimizing metabolic and hormonal rhythms.
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