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Time-Domain of Hormonal Expression

Meaning

The Time-Domain of Hormonal Expression refers to the critical temporal patterns, including the circadian, ultradian, and pulsatile rhythms, that govern the synthesis, secretion, circulation, metabolism, and clearance of hormones. Understanding this domain is paramount in clinical endocrinology, as the biological effect of a hormone is highly dependent on when and how it is released, not just its overall average concentration. Dysregulation in this domain, such as blunted pulsatility or phase shifts, is a hallmark of endocrine aging.