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Tight Junction Integrity

Meaning

Tight Junction Integrity refers to the robust, functional state of the complex protein structures that effectively seal the minute space between adjacent epithelial cells, most critically in the intestinal mucosal lining. These junctions function as a highly selective semi-permeable barrier, meticulously regulating the passage of digested nutrients while simultaneously blocking the translocation of pathogens, microbial toxins, and large, undigested macromolecules into the systemic circulation. Maintaining this integrity is fundamental to immune regulation, reducing systemic inflammation, and supporting optimal hormonal metabolism.