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Thyroid Pharmacogenomics

Meaning

Thyroid Pharmacogenomics is a specialized sub-discipline that investigates how an individual’s unique genetic makeup influences their therapeutic response to pharmacological agents used to treat thyroid dysfunction, such as levothyroxine or anti-thyroid medications. This field aims to identify specific genetic polymorphisms that predict variations in drug metabolism, transport kinetics, and target receptor sensitivity, ultimately enabling the personalization of thyroid hormone replacement or suppressive therapy. The goal is to improve clinical efficacy and minimize adverse drug reactions.