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Thyroid Peroxidase Antibodies

Meaning

Thyroid Peroxidase Antibodies, or TPOAb, are autoantibodies directed against the enzyme thyroid peroxidase (TPO), which is critical for the synthesis of thyroid hormones in the thyroid gland. The presence of these antibodies in the bloodstream is a primary clinical marker for autoimmune thyroid disease, most commonly Hashimoto’s thyroiditis, which leads to chronic inflammation and eventual hypothyroidism. Their detection is crucial for the differential diagnosis of thyroid dysfunction.