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Thyroid Hormone Tissue Responsiveness

Meaning

Thyroid Hormone Tissue Responsiveness describes the functional sensitivity and efficiency with which target cells and tissues across the body react to the circulating levels of active thyroid hormone, primarily triiodothyronine (T3). This responsiveness is a crucial determinant of metabolic rate, energy production, and overall systemic vitality, often more clinically relevant than mere serum hormone concentrations. Diminished responsiveness, or resistance, can lead to hypothyroid symptoms despite seemingly normal lab values. Optimizing this cellular response is key to true thyroid health.