What is the Origin of Thyroid Hormone T3 T4?

This is a core term in endocrinology, referring to the chemical structures and physiological roles of the main thyroid gland secretions. The abbreviations T3 and T4 denote the number of iodine atoms attached to the thyronine molecule.

What is the Mechanism of Thyroid Hormone T3 T4?

T4 is secreted in greater quantity but must be converted to the more potent T3, primarily in peripheral tissues, by deiodinase enzymes. T3 then enters the cell nucleus and binds to thyroid hormone receptors, modulating gene transcription to increase mitochondrial activity and overall cellular metabolism. Dysregulation in production or conversion can lead to widespread metabolic slowdown or acceleration.

Thyroid Hormone T3 T4 ∞ Area

Thyroid Hormone T3 T4

Meaning

The two primary iodothyronine hormones produced by the thyroid gland: Thyroxine (T4), the prohormone, and Triiodothyronine (T3), the metabolically active form. These hormones are essential regulators of the body’s basal metabolic rate, influencing oxygen consumption, protein synthesis, and the metabolism of carbohydrates, lipids, and vitamins across nearly all cell types. Their balance is fundamental to energy homeostasis and thermal regulation.