What is the Origin of Thyroid Hormone Signaling Pathways?

This is a foundational concept in endocrinology, originating from the discovery of the thyroid gland's role in regulating metabolism and development. The focus here is on the downstream genomic and non-genomic actions of the hormones.

What is the Mechanism of Thyroid Hormone Signaling Pathways?

$text{T3}$ enters the cell and binds to the Thyroid Hormone Receptor complex, often displacing corepressors and recruiting coactivators, thereby directly modulating the transcription of genes involved in mitochondrial function, protein synthesis, and carbohydrate metabolism. Efficient signaling ensures appropriate basal energy expenditure and supports the necessary metabolic rate for optimal anabolic hormone function.

Thyroid Hormone Signaling Pathways ∞ Area

Thyroid Hormone Signaling Pathways

Meaning

Thyroid Hormone Signaling Pathways encompass the cascade of events initiated by the binding of active thyroid hormones, primarily $text{T3}$, to nuclear receptors ($text{TRs}$) to regulate gene transcription across nearly every cell type in the body. These pathways are central to basal metabolic rate and cellular energy metabolism.