Skip to main content

Thyroid Hormone Sensitivity

Meaning

The responsiveness of target cells and tissues throughout the body to the circulating concentrations of active thyroid hormones, primarily triiodothyronine (T3). This sensitivity is a dynamic biological characteristic, modulated by the density and function of nuclear thyroid hormone receptors and the activity of deiodinase enzymes. Optimal sensitivity is essential for the appropriate regulation of basal metabolic rate, thermogenesis, and protein synthesis.