Skip to main content

Thyroid Hormone Responsiveness

Meaning

Thyroid Hormone Responsiveness is the measure of how effectively peripheral tissues and cells respond to the circulating levels of active thyroid hormones, primarily triiodothyronine (T3), which is a critical determinant of metabolic rate and cellular energy production. This responsiveness is mediated by the density and function of nuclear thyroid hormone receptors (TRs) and the efficiency of T4-to-T3 conversion at the cellular level. Suboptimal responsiveness, even with normal serum hormone levels, can lead to hypothyroid symptoms like fatigue and weight gain.