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Thyroid Hormone Receptor

Meaning

The Thyroid Hormone Receptor (TR) is a nuclear receptor protein that functions as a ligand-activated transcription factor, mediating the widespread biological effects of thyroid hormones, primarily the active form triiodothyronine ($text{T}_3$). These receptors are expressed in nearly every cell type and are crucial for regulating basal metabolic rate, thermogenesis, protein synthesis, growth, and cellular differentiation. Their functional status and density are key determinants of an individual’s overall metabolic and developmental health across the lifespan.