Thyroid Hormone Efficacy

Meaning

Thyroid Hormone Efficacy refers to the overall effectiveness with which the thyroid hormones, primarily triiodothyronine (T3) and thyroxine (T4), are able to bind to their nuclear receptors and successfully modulate gene expression and metabolic rate in target tissues. High efficacy signifies an optimal cellular response to circulating hormone levels, translating to robust energy metabolism, thermal regulation, and neurocognitive function. Impaired efficacy can lead to clinical symptoms despite normal circulating hormone concentrations.

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